Here are the chances of taking out one particular number in each round e.g. £250,000
Round 1
(1/22)+(1/21 x 20/21)+(1/20 x 19/20)+(1/19 x 18/19)+(1/18 x 17/18 )
= 24.06 (2dp)
Round 2
(1/17)+(1/16 x 15/16)+(1/15 x 14/15)
= 17.96% (2dp)
Round 3
(1/14)+(1/13 x 12/13)+(1/12 x 11/12)
= 21.88% (2dp)
Round 4
(1/11)+(1/10 x 9/10)+(1/9 x 8/9)
= 27.97% (2dp)
Round 5
(1/8 )+(1/7 x 6/7)+(1/6 x 5/6)
= 39.29% (2dp)
Round 6
(1/5)+(1/4 x 3/4)+(1/3 x 2/3)
= 65%
The reason Round 1's chances are higer than Rounds 2 and 3's are because you open more boxes in Round 1, so there is a greater chance of hitting a big number in that round.
Thanks MisterAl, these are sorted now